Baby Development in Utero Pbs Conception to Birth

Fetal Development

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Embryology - 15 Mar 2022  Expand to Translate
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Introduction

This page shows some key events of human evolution during the fetal period (weeks 9 to 37) post-obit fertilization. The long Fetal period (4x the embryonic period) is a time of extensive growth in size and mass equally well equally ongoing differentiation of organ systems established in the embryonic menses. Clinically this period is mostly described as the 2d Trimester and Third Trimester. Many of the disquisitional measurements of growth are at present carried out by ultrasound and this period ends at birth. Many dissimilar systems formed in the embryonic menses (organogenesis) grow and differentiate further during the fetal period and practice then at different times. For example, the brain continues to abound and develop extensively during this menstruation (and postnatally), the respiratory system differentiates (and completes only just before nativity), the urogenital system farther differentiates between male/female, endocrine and gastrointestinal tract begins to function. Also consider the systems (respiratory, cardiac, neural) that will still non have their final organization and function determined until after nativity.

Irresolute fetal proportions, non size growth. Click Here to play on mobile device | motion-picture show folio

Use the links beneath to get more detailed information about this menstruation of evolution.

Historic Embryology

In 1949 the embryologist George Streeter[1] used the replacement of cartilage inside the humerus past bone marrow as an capricious definition of the embryo to fetus transition. "If the onset can be recognized in a given specimen, that specimen is straightway classed equally a fetus."

Fetal Links: fetal | Week ten | Week 12 | 2d trimester | third trimester | fetal neural | Fetal Blood Sampling | fetal growth restriction | birth | nativity weight | preterm birth | Developmental Origins of Wellness and Illness | macrosomia | BGD Practical | Medicine Lecture | Scientific discipline Lecture | Lecture Movie | Category:Human Fetus | Category:Fetal

Historic Embryology 1940 Fetus Physiology Carnegie Fetal: 95 | 96 | 142 | 145 | 184 | 211 | 217 | 300 | 362 | 448 | 449 | 538 | 590 | 607 | 625 | 662 | 693 | 847 | 858 | 922 | 928 | 948 | 972 | 1318 | 1388 | 1455 | 1591 | 1597b | 1656 | 1686 | 2250a | 2250b | 3990 | 5652 | 6581 | 7218

Fetal Graphs: Crown-Rump Length (CRL) | Third trimester CRL | Head Circumference | Head Circumference 2nd Trimester | Liver Weight | Pancreas Weight | Thymus Weight | Small Intestine Length | Big Intestine Length | Length and Weight Changes | Fetal Evolution

Some Recent Findings

• Functional connectome of the fetal brain ^[2] "Large-calibration functional connectome formation and re-organisation is credible in the 2nd trimester of pregnancy, making information technology a crucial and vulnerable time window in connectome development. Here nosotros identified which architectural principles of functional connectome organization are initiated prior to birth, and contrast those with topological characteristics observed in the mature adult brain. A sample of 105 significant women participated in human fetal resting-state fMRI studies (fetal gestational age between xx and 40 weeks). Connectome analysis was used to clarify weighted network characteristics of fetal macroscale brain wiring. We identified efficient network attributes, common functional modules and loftier overlap between the fetal and adult encephalon network. Our results bespeak that key features of the functional connectome are nowadays in the second and 3rd trimesters of pregnancy. Agreement the organizational principles of fetal connectome organization may bring opportunities to develop markers for early on detection of alterations of brain part. The fetal to neonatal period is well known as a disquisitional stage in brain development. In this study, nosotros evaluate the network topography of normative functional network development during connectome genesis in utero Agreement the developmental trajectory of encephalon connectivity provides a basis for understanding how the prenatal period shapes futurity brain function and disease dysfunction." neural

• Fetal brain growth portrayed by a spatiotemporal improvidence tensor MRI atlas computed from in utero images ^[3] "Altered structural fetal brain evolution has been linked to neuro-developmental disorders. These structural alterations tin can be potentially detected in utero using improvidence tensor imaging (DTI). However, conquering and reconstruction of in utero fetal brain DTI remains challenging. Until now, motion-robust DTI methods have been employed for reconstruction of in utero fetal DTIs. However, due to the unconstrained fetal motion and permissible in utero conquering times, these methods yielded express success and have typically resulted in noisy DTIs. Consequently, atlases and methods that could enable groupwise studies, multi-modality imaging, and computer-aided diagnosis from in utero DTIs take not yet been adult. This paper presents the beginning DTI atlas of the fetal encephalon computed from in utero diffusion-weighted images. For this purpose an algorithm for computing an unbiased spatiotemporal DTI atlas, which integrates kernel-regression in historic period with a diffeomorphic tensor-to-tensor registration of motion-corrected and reconstructed individual fetal brain DTIs, was developed. Our new algorithm was applied to a set of 67 fetal DTI scans acquired from healthy fetuses each scanned at a gestational age between 21 and 39 weeks. The neurodevelopmental trends in the fetal brain, characterized by the atlas, were qualitatively and quantitatively compared with the observations reported in prior ex vivo and in utero studies, and with results from imaging gestational-historic period equivalent preterm infants. Our major findings revealed early presence of limbic fiber bundles, followed by the advent and maturation of projection pathways (characterized by an age related increase in FA) during late 2nd and early on tertiary trimesters. During the 3rd trimester clan fiber bundles become evident. In parallel with the appearance and maturation of fiber bundles, from 21 to 39 gestational weeks gradual disappearance of the radial coherence of the telencephalic wall was qualitatively identified. These results and analyses show that our DTI atlas of the fetal brain is useful for reliable detection of major neuronal cobweb packet pathways and for characterization of the fetal encephalon reorganization that occurs in utero. The atlas tin also serve every bit a useful resources for detection of normal and abnormal fetal brain development in utero."

• Stresses and strains on the homo fetal skeleton during development ^[4] "Mechanical forces generated by fetal kicks and movements result in stimulation of the fetal skeleton in the form of stress and strain. This stimulation is known to exist critical for prenatal musculoskeletal evolution; indeed, aberrant or absent movements have been implicated in multiple congenital disorders. Yet, the mechanical stress and strain experienced past the developing homo skeleton in utero take never before been characterized. Here, we quantify the biomechanics of fetal movements during the 2d half of gestation by modelling fetal movements captured using novel cine-magnetic resonance imaging applied science. ...We find that fetal boot strength increases significantly from 20 to thirty weeks' gestation, before decreasing towards term. Nonetheless, stress and strain in the fetal skeleton rises significantly over the latter half of gestation. This increasing tendency with gestational age is important considering changes in fetal movement patterns in late pregnancy have been linked to poor fetal outcomes and musculoskeletal malformations."

• The part of three-dimensional ultrasonography fetal lung volume measurement in the prediction of neonatal respiratory role outcome ^[5] "Respiratory distress is commonly encountered amidst premature babies immediately later birth resulting in significant neonatal morbidity or bloodshed. To evaluate the possible correlation betwixt three dimensional fetal lung volumes (FLVs) and neonatal respiratory outcomes. A cohort written report included 100 meaning women who participated in the study and were divided into two groups; group A (northward: fifty - women pregnant ±34-37 weeks) and group B (northward: fifty - women pregnant ±37+one to twoscore weeks). A iii dimensional measurement of the right fetal lung was fabricated using virtual organ computer-aided analysis (Vocal) software so correlated to neonatal respiratory functions namely Apgar score at nascency and the occurrence of respiratory distress syndrome (RDS). In group A, FLV was negatively correlated with Apgar score and the occurrence of RDS. In group B, FLV showed no statistical correlation with Apgar score and the occurrence of RDS. Three dimensional fetal lung volumes might be an accurate noninvasive predictor for the development of RDS amongst preterm fetuses."

More recent papers

This table allows an automatic computer search of the external PubMed database using the listed "Search term" text link. This search now requires a transmission link every bit the original PubMed extension has been disabled. The displayed list of references exercise non reflect whatever editorial option of material based on content or relevance. References as well appear on this list based upon the appointment of the actual page viewing. References listed on the residual of the content page and the associated discussion page (listed under the publication twelvemonth sub-headings) do include some editorial selection based upon both relevance and availability. More than? References | Discussion Page | Journal Searches | 2019 References | 2020 References Search term: Fetal Evolution | Foetal Development | Second Trimester | Third Trimester

Older papers

These papers originally appeared in the Some Recent Findings tabular array, but as that list grew in length have at present been shuffled down to this collapsible table. See too the Discussion Page for other references listed by year and References on this current folio. Size and location of the kidneys during the fetal period [half dozen] "The level of the left kidney was higher than the level of the right kidney in the fetal period. The posterior surface relations to the ribs showed certain ascendance during gestation, corresponding to vertebral levels. Withal, fetal kidneys do not reach the aforementioned level every bit adults at full term. The kidneys move farther apart from the midline of the body during the fetal menstruation. The dimensions, weight, and book of the kidneys increased with gestational age during the fetal period. The ratio between kidney weights and fetal trunk weights were determined, and we observed that the ratio decreased during the fetal menstruation. At that place were no sex or laterality differences in any parameter." (Come across likewise Renal System Development) Evolution and Function of the Human Fetal Adrenal Cortex: A Central Component in the Feto-Placental Unit of measurement [7] "The steroidogenic activity is characterized by early transient cortisol biosynthesis, followed by its suppressed synthesis until belatedly gestation, and extensive product of dehydroepiandrosterone and its sulfate, precursors of placental estrogen, during most of gestation. The gland apace grows through processes including cell proliferation and angiogenesis at the gland periphery, cellular migration, hypertrophy, and apoptosis." (See also Endocrine - Adrenal Development)

Reading

Human Embryology (3rd ed.) Larson Chapter 15: Fetal evolution and the Fetus as Patient p481-499 The Developing Human: Clinically Oriented Embryology (8th ed.) Moore and Persaud Chapter 6: The Fetal Menstruation: Ninth Week to Nascency Colour Atlas of Clinical Embryology (2nd ed.) Moore, Persaud and Shiota Affiliate 3: 9th to 38th weeks of human evolution p50-68

Fetal length and weight change

Fetal Development - Length - Weight
Gestational age	Fertilization age	Length	Mass
(LMP) (GA weeks)	(weeks)	(cm)	(g)
8 (embryonic)	six	1.6 (crown to rump)	1
9	7	2.3	2
10	viii	three.ane	four
11 (fetal)	nine	4.1	seven
12	10	five.iv	14
13 (second trimester)	xi	7.iv	23
14	12	viii.7	43
15	thirteen	10.1	lxx
sixteen	14	xi.six	100
17	15	thirteen	140
eighteen	xvi	xiv.2	190
19	17	xv.3	240
20	18	16.4 25.6 (crown to heel)	300
21	19	26.seven	360
22	twenty	27.8	430
23	21	28.9	501
24	22	30	600
25	23	34.half-dozen	660
26	24	35.vi	760
27	25	36.6	875
28 (3rd trimester)	26	37.6	1005
29	27	38.half dozen	1153
30	28	39.9	1319
31	29	41.1	1502
32	30	42.iv	1702
33	31	43.7	1918
34	32	45	2146
35	33	46.2	2383
36	34	47.4	2622
37	35	48.6	2859
38	36	49.eight	3083
39	37	l.7	3288
forty	38	51.2	3462
41	39	51.seven	3597
42	xl	51.5	3685
References [8] [ix] [10]

Ultrasound CRL Data

The collapsed tabular array beneath shows measurement data from a recent ultrasound study.^[eleven]

Fertilization and Gestational Age - Crown-Rump Length (ultrasound)

Fertilization Age (days) Gestational Age GA (week.twenty-four hours) Crown-Rump Length (mm) 37 5.2 1 38 5.iii 2 39 5.four 3 xl 55 3 41 five.6 iv 42    Calendar week 4 half dozen 4 43 6.i 5 44 6.ii 6 45 6.3 seven 46 6.four 8 47 vi.v ix 48 half dozen.half dozen 10 49    Week five 7 11 50 7.i 11 51 vii.2 12 52 7.three 12 53 7.four xiii 54 7.5 fourteen 55 seven.6 15 56    Calendar week 6 8 17 57 8.1 xviii 58 viii.2 19 59 eight.3 20 sixty 8.4 21 61 8.5 22 62 eight.6 22 63    Calendar week seven 9 23 64 ix.1 24 65 9.2 26 66 9.3 27 67 9.4 28 68 ix.v 29 69 9.half-dozen 31 lxx    Week viii 10 34 71 10.one 36 72 10.2 37 73 ten.3 38 74 x.4 39 75 10.5 39 76 10.vi twoscore 77    Week 9 eleven 44 78 11.one 45 79 11.2 47 eighty eleven.3 48 81 eleven.4 52 82 xi.v 55 83 11.vi 56 84    Week 10 12 57 85 12.1 58 86 12.two 60 87 12.3 61 88 12.4 63 89 12.5 64 90 12.half-dozen 65 91    Week 11 13 68 92 thirteen.ane 70 93 13.2 72 94 thirteen.three 74 95 113.4 76 96 135 77 97 13.6 80 98    Week 12 fourteen 81 99 fourteen.i 84 100 14.2 85 101 14.iii 86 102 14.4 87 Reference: Table data measured by ultrasound, adapted from Westerway (2015) PDF and[xi] Links: ultrasound | Fetal Development

Second Trimester

Fetus - second trimester
(ultrasound)

• Second Trimester
• Calendar week 12 - CRL 85 mm, femur length 15 mm, biparietal bore 25 mm.

Begin by working through the features present in the early 10 week female person fetus. And so look in item at the head development in a 12 week fetus.

Week 13 to Week 16

(GA Week 15-eighteen)

• Growth - rapid growth continues
• Head - caput has straightened upwards
  • eyes at the front part of the face up but nonetheless widely separated
  • outer ear has moved (relatively) from upper role of neck to the side of the caput
• Musculoskeletal - ossification is proceeding
  • skeleton now visible on an x-ray
• Integumentary - trunk is covered with lanugo

Week 17 to Week 20

(GA Week xix-21)

• Growth - Length growth begins to slow.
  • body parts have caused their relative proportions.
• Integumentary - vernix caseosa
  • sebaceous glands begin to secrete and vernix caseosa comes to embrace the skin to prevent harm by amniotic fluid.
• Neural - Spinal cord myelinization begins
• Adipose Tissue - chocolate-brown fat is forming
• Musculoskeletal - active movements of the fetus in the uterus (kicks)

Week 21 to Week 25

(GA Calendar week 23-27)

• Integumentary / Vision - eyelids and eyebrows developed
  • lanugo a darker color and vernix caseosa is thicker.
  • skin is sometimes very wrinkled (high growth, lack of subcutaneous fatty)
  • fingernails are visible
• Growth - face up and torso are commonly as they will be at birth.
• Fetuses built-in after the 25th week of gestation are generally viable

ten Week Fetus caput images

Then wait in detail at the head evolution in a 12 week fetus showing both forms of ossification in the skull.

12 Week Fetus head images

Timeline

Second Trimester Timeline

Links: human timeline | first trimester timeline | 2d trimester timeline | third trimester timeline
Calendar week	Stage	Issue
12	Clinical second trimester	Week 12 - CRL 85 mm, femur length fifteen mm, biparietal diameter 25 mm Hearing Week 12-16 - Capsule adjacent to membranous labrynth undegoes vacuolization to form a cavity (perilymphatic space) effectually membranous labrynth and fills with perilymph Genital male and female external genital differences appreciable Respiratory Month three-6 - lungs announced glandular, end month half dozen alveolar cells blazon 2 appear and begin to secrete surfactant Tongue Week 12 - showtime differentiated epithelial cells (Type Two and III) Genital female genital canal (80 days) formed with absorption of the median septum
thirteen		natural language Week 12 to 13 - maximum synapses between cells and afferent nerve fibers hearing outer ear Week 13 - Meatal plug disc-like, innermost surface in contact with the primordial malleus, contributes to the formation of the tympanic membrane.
14		tongue Week 14 to 15 - gustation pores develop, mucous ovary 100 days - master follicles present nail toenails announced Head Evolution facial skeleton remodelling begins Hearing - Inner Ear Evolution Calendar week 14 GA 16 - neural-crest-derived melanocytes, now intermediate cells of the stria vascularis, tightly integrate with Na+ /Thou+ -ATPase-positive marginal cells, which started to express KCNQ1 in their upmost membrane.[12]
15		Pancreas glucagon detectable in fetal plasma. spleen Calendar week xv -blastoff-shine musculus actin (alpha-SMA)-positive reticulum cells scattered effectually the arterioles.[13]
xvi	14 cm	Hearing Week 16-24 - Centres of ossification announced in remaining cartilage of otic sheathing course petrous portion of temporal bone. Continues to ossify to form mastoid process of temporal bone. pituitary adenohypophysis fully differentiated respiratory Week 16 to 25 lung histology - canalicular Hearing - Outer Ear Development Calendar week sixteen.5 - External auditory meatus is fully patent throughout its length, lumen is still narrow and curved. Hearing - Inner Ear Development Week sixteen GA 18 - cells in the outer sulcus express KCNJ10 and gap junction proteins GJB2/CX26 and GJB6/CX30, but these are not expressed in the screw ligament.[12] gap junction cartoon neural - Cerebrum development of the periinsular sulci (week 16-17, GA 18-19 weeks)[xiv] integumentary 4 months - basal cell- proliferation generates folds in basement membrane; neural crest cells- (melanocytes) migrate into epithelium; embryonic connective tissue- differentiates into dermis, a loose ct layer over a dumbo ct layer. Beneath the dense ct layer is some other loose ct layer that volition form the subcutaneous layer. Ectoderm contributes to nails, hair follictles and glands. Nails form equally thickening of ectoderm epidermis at the tips of fingers and toes. These form germinative cells of nail field. Cords of these cells extend into mesoderm forming epithelial columns. These form hair follocles, sebaceous and sweat glands. primary follicles begin to course in the ovary and are characterized past an oocyte glandular urethra forms and skin folds present
17		Neural - Brain evolution histology week 17 Cerebellum Magnetic Resonance Imaging (MRI) tin can study the developing cerebellum from 17 to 18 weeks (GA 19 to xx weeks). molar Calendar week 17 - First papilla of the permanent dentition announced (first molar) immediately behind the 2nd milk molar, milk teeth are well advanced (Fetus 180 mm).
18		tongue Week eighteen - substance P detected in dermal papillae, not in taste bud primordia integumentary vernix caseosa covers pare spleen Calendar week 18 - alpha-SMA-positive reticulum cells increment in number and began to course a reticular framework. An accumulation of T and B lymphocytes occurred inside the framework, and a primitive white pulp was observed around the arterioles.[13] Hearing - Outer Ear Development calendar week 18 - External auditory meatus is already fully expanded to its complete form. neural - Cerebrum central sulci and opercularization of the insula (week 18-xx, GA 20-22 weeks)[14]
xix		neural calendar week 19 neuronal migration ends and the radial glial cells that aided the migration at present become transformed into astrocytes and astrocytic precursors.[15]
20		pituitary week twenty to 24 growth hormone levels peak, then decline integumentary lanugo, skin pilus integumentary 5 months - Hair growth initiated at base of cord, lateral outgrowths form associated sebaceous glands; Other cords elongate and roll to form sweat glands; Cords in mammary region branch every bit they elongate to grade mammary glands. touch pacinian corpuscle begin to develop[sixteen]
21
22		Neural encephalon cortical sulcation - sylvian crack, interhemispheric fissure, callosal sulcus, parietooccipital crevice, and hippocampic fissures present[17] spleen - Week 22 - antigenic diversity of the reticular framework was observed, and T and B lymphocytes were segregated in the framework. T lymphocytes were sorted into the alpha-smooth muscle actin-positive reticular framework, and the periarteriolar lymphoid sheath (PALS) was formed around the arteriole. B lymphocytes aggregated in eccentric portions to the PALS and formed the lymph follicle (LF). The reticular framework of the LF was alpha-SMA-negative. [13] neural - Cerebrum covering of the posterior insula (week 22-24, GA 24-26 weeks)[14]
23
24		respiratory Week 24 to 40 lung histology - concluding sac spleen Week 24 - marginal zone appeared in the blastoff-smooth muscle actin-positive reticular framework around the white pulp.[thirteen] tooth Week 24 - Permanent incisors and canines appear. Earliest potential survival expected if born ovary follicles can consist of growing oocytes surrounded past several layers of granulosa cells
25		respiratory end calendar month 6 alveolar cells blazon ii announced and brainstorm to secrete surfactant neural - Cerebrum closure of the laeteral sulcus (Sylvian scissure or lateral fissure) (week 25-26, GA 27-28 weeks)[14]
26		touch pacinian corpuscle well developed[16]
	Systems Systems: bone timeline | eye neural crest timeline | heart aberration timeline | hearing EAM timeline | muscle timeline | ovary timeline | placental villi timeline | shoulder timeline | odour timeline | spleen timeline | ventricular timeline

Third Trimester

Fetus - third trimester
(historic image)

Third trimester Crown-Rump Length

• Vibration acoustically of maternal abdominal wall induces startle respone in fetus.
• Month vii - respiratory bronchioles proliferate and end in alveolar ducts and sacs.
• Week 37 to 38 Birth.

Week 26 to Calendar week 29

(GA Week 28-31)

• Integumentary / Vision - eyes are opened again and eyebrows and eyelashes are well formed
  • pupillary membrane disappears.
• Integumentary - hair grows, subcutaneous adipose tissue deposits circular the whole body, becomes stubby and plump

Week xxx to Week 34

(GA Week 32-36)

• Integumentary - torso becomes chubby and the pare is pink
  • fingernails have reached the ends of the fingers
  • toenails are visible
• Genital - testicles descend

Timeline

Third Trimester Timeline

Links: human timeline | first trimester timeline | second trimester timeline | third trimester timeline
Calendar week	Stage	Event
	Clinical third trimester	hearing third Trimester - vibration acoustically of maternal abdominal wall induces startle respone in fetus.
27
28		respiratory Calendar month 7 - respiratory bronchioles proliferate and end in alveolar ducts and sacs
29		tooth Week 29 - Permanent premolars (correspond to the milk molars) appear.
xxx		Genital male person gonad (testes) descending
31
32		blast fingernails accomplish digit tip
33		neural encephalon cortical sulcation - principal sulci present[17]
34		neural brain cortical sulcation - insular, cingular, and occipital secondary sulci present[17]
35
36		Nail Evolution toenails reach digit tip Lens Development - lens growth and interocular distance plateaus after 36 weeks of gestation[18]
37
38	Birth	Clinical Calendar week twoscore Heart pressure difference closes foramen ovale leaving a fossa ovalis thyroid TSH levels increase, thyroxine (T3) and T4 levels increase to 24 h, and then 5-7 days postnatal turn down to normal levels adrenal - zona glomerulosa, zona fasiculata present
	Systems Systems: os timeline | eye neural crest timeline | center aberration timeline | hearing EAM timeline | muscle timeline | ovary timeline | placental villi timeline | shoulder timeline | smell timeline | spleen timeline | ventricular timeline

Links: Tertiary Trimester

Growth

Fetal Head Growth

Second trimester	Second and third trimesters

Fetal Neural

Relative encephalon size embryonic (week four, v, 6, and 8) and belatedly fetal (third trimester)

During the fetal flow at that place is ongoing growth in size, weight and surface expanse of the encephalon and spinal cord. Microscopically at that place is ongoing: cell migration, extension of processes, jail cell death and glial jail cell development. Brain - folding of the initially polish surface (Insular cortex, Gyral and Sulcal development) Neural development volition continue after nascence with substantial growth, death and reorganization occuring during the postnatal menstruum

Fetal Fissure Development	Timeline Neural Development
Links: Scaled Fissures xiii-21 weeks | Fissures 13-21 weeks | Brain Sylvian Cleft | Scaled Brain and Ventricles 13-21 weeks | Scaled Brain, Ventricles and Ganglia 13-21 weeks | Limbic Tract 13-19 weeks | Brain and Ventricles 13-21 weeks | Sylvian Crack Pic | Neural System Development | Magnetic Resonance Imaging	Timeline human evolution

Links: Neural System Development

|}

Fetal Endocrine

Pituitary Hormones

• HPA axis established by calendar week xx
• Pituitary functional throughout fetal development

Thyroid Hormone

• required for metabolic activity, also in the newborn
• of import for neural evolution

Parathyroid Hormone

• newborn has total calcium levels (approx 20 grams) accumulated mainly in the tertiary trimester (weeks 28–40)
• fetal parathyroid hormone (PTH) potentially bachelor from 10–12 weeks and PTH does not cantankerous the placenta
• fetus relatively hypercalcemic, active transplacental transport of Ca²⁺ to fetus
• maternal serum - calcium ions (Ca^two+), inorganic phosphate (Pi) and PTH concentrations are within the non-significant normal range throughout pregnancy.
• maternal bone turnover increases in the 3rd trimester.

(Based on Endocrinology - Materno—fetal calcium residue)

Pancreatic Hormones

• maternal diabetes can affect fetal pancreas evolution (increase in fetal islet beta cells).

Gonadal Hormones

• testosterone - required during fetal development for external genital development and internal genital tract in male person.
• estrogens - secreted inactive precursor converted to agile form past placenta.

Links: Endocrine Arrangement Evolution | Endocrinology - Command of steroid product in the fetal gonads | Neuroscience - The Issue of Sexual practice Hormones on Neural Circuitry

Fetal Respiratory

• calendar week four - five embryonic
• week 5 - 17 pseudoglandular
• week 16 - 25 canalicular
• week 24 - forty concluding sac
• late fetal - 8 years alveolar

Links: Respiratory System Development

Fetal Genital

• ovary and testis development
• external genital evolution
• testis descent

Tests descent offset	Tests descent end

Links: Genital System Development

Fetal Renal

Human fetal kidney (GA week 12)

• week 32-34 nephron development completed
• term nascency nephron number per kidney well-nigh 1 1000000 (300,000 to 2 million)

Nephron development has 4 identifiable developmental stages:

1. Vesicle (V) phase (13-19 weeks, second trimester)
2. S-shaped body (S) stage ( 20-24 weeks, second trimester)
3. Capillary loop (C) stage (25-29 weeks, third trimester)
4. Maturation (M) phase (infants anile 1-half dozen months, neonatal and postnatal)

Links: Fetal Renal | renal

Fetal Gastrointestinal

Fetal developmental features include: the growth and rotation of intestines initially herniated outside the ventral body wall; changes in mesenteries; development of the claret supply and tract wall.

The initial functions of the tract with amionic fluid swallowing and the accumulation of both secretions and swallowed components within the large intestine every bit meconium.

Links: intestine | gastrointestinal

Fetal Integumentary

4 months basal cell - proliferation generates folds in basement membrane. neural crest cells - (melanocytes) migrate into epithelium. These are the paint cell of the skin. embryonic connective tissue - differentiates into dermis, a loose ct layer over a dense ct layer. Below the dense ct layer is another loose ct layer that will form the subcutaneous layer. Ectoderm contributes to nails, hair follicles and glands. Cords of these cells extend into mesoderm forming epithelial columns. These class pilus follicles, sebaceous and sweat glands. Nails course equally thickening of ectoderm epidermis at the tips of fingers and toes. These form germinative cells of nail field. 5 months Hair growth initiated at base of operations of cord, lateral outgrowths form associated sebaceous glands. Other cords elongate and scroll to form sweat glands. Cords in mammary region branch as they elongate to form mammary glands. These glands will complete development in females at puberty. Functional maturity but occurs in late pregnancy.

Links: integumentary

Fetal Palate

Levator veli palatini skeletal muscle contacted by the bottom palatine nerve.^[19] The lesser palatine nervus (posterior palatine nerve) is a branch of the maxillary nervus (CN V2), one of two palatine fretfulness that descends through the greater palatine culvert, and emerges by the lesser palatine foramen

Links: palate

Fetal Surgical Procedures

There are a range of fatal abnormalities that are potentially amenable to surgical intervention, see recent review link Maternal-Fetal Surgical Procedures.^[twenty]

Some examples include:

• Cardiac Malformations
• Congenital Diaphragmatic Hernia
• Myelomeningocele/Spina Bifida
• Obstructive Uropathy
• Sacrococcygeal Teratoma
• Thoracic Lesions
• Twin-Twin Transfusion Syndrome

Maternal

In that location are many maternal physiological changes during and later pregnancy. This department introduces just the anatomical changes that must occur to simply accomodate the growing fetus.

Make Room for Baby! (2017)

The Position of the Uterus and Fetus at Term (1872).^[21]

Links: Maternal Development | MP4 | Museum of Science and Industry, Chicago - Make Room for Baby! | YouTube

References

1. ↑ Streeter GL. Developmental horizons in human embryos (fourth issue). A review of the histogenesis of cartilage and bone. (1949) Carnegie Instn. Wash. Publ. 583, Contrib. Embryol., 33: 149-169. PMID: 18144445
2. ↑ Turk E, van den Heuvel MI, Benders MJ, de Heus R, Franx A, Manning JH, Hect JL, Hernandez-Andrade Due east, Hassan SS, Romero R, Kahn RS, Thomason ME & van den Heuvel MP. (2019). Functional connectome of the fetal brain. J. Neurosci. , , . PMID: 31685648 DOI.
3. ↑ Khan South, Vasung L, Marami B, Rollins CK, Afacan O, Ortinau CM, Yang Eastward, Warfield SK & Gholipour A. (2019). Fetal brain growth portrayed by a spatiotemporal diffusion tensor MRI atlas computed from in utero images. Neuroimage , 185, 593-608. PMID: 30172006 DOI.
4. ↑ Verbruggen SW, Kainz B, Shelmerdine SC, Hajnal JV, Rutherford MA, Arthurs OJ, Phillips ATM & Nowlan NC. (2018). Stresses and strains on the human fetal skeleton during evolution. J R Soc Interface , 15, . PMID: 29367236 DOI.
5. ↑ Maged A, Youssef One thousand, Hussien A, Gaafar H, Elsherbini Grand, Elkomy R, Eid Thousand, Abd El-Hamid Northward & Abdel-Razek AR. (2019). The role of three-dimensional ultrasonography fetal lung volume measurement in the prediction of neonatal respiratory function outcome. J. Matern. Fetal. Neonatal. Med. , 32, 660-665. PMID: 28969488 DOI.
6. ↑ Sulak O, Ozgüner G & Malas MA. (2011). Size and location of the kidneys during the fetal flow. Surg Radiol Anat , 33, 381-viii. PMID: 21110022 DOI.
7. ↑ Ishimoto H & Jaffe RB. (2011). Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr. Rev. , 32, 317-55. PMID: 21051591 DOI.
8. ↑ Cussen 50, Scurry J, Mitropoulos G, McTigue C & Gross J. (1990). Hateful organ weights of an Australian population of fetuses and infants. J Paediatr Child Wellness , 26, 101-3. PMID: 2361065
9. ↑ Hansen K, Sung CJ, Huang C, Pinar H, Singer DB & Oyer CE. (2003). Reference values for second trimester fetal and neonatal organ weights and measurements. Pediatr. Dev. Pathol. , 6, 160-seven. PMID: 12548377 DOI.
10. ↑ Archie JG, Collins JS & Lebel RR. (2006). Quantitative standards for fetal and neonatal autopsy. Am. J. Clin. Pathol. , 126, 256-65. PMID: 16891202 DOI.
11. ↑ ^{xi.0 11.1} Westerway SC, Davison A & Cowell Southward. (2000). Ultrasonic fetal measurements: new Australian standards for the new millennium. Aust Due north Z J Obstet Gynaecol , forty, 297-302. PMID: 11065037
12. ↑ ^{12.0 12.1} Locher H, de Groot JC, van Iperen L, Huisman MA, Frijns JH & Chuva de Sousa Lopes SM. (2015). Development of the stria vascularis and potassium regulation in the human fetal cochlea: Insights into hereditary sensorineural hearing loss. Dev Neurobiol , 75, 1219-40. PMID: 25663387 DOI.
13. ↑ ^{thirteen.0 13.1 13.2 13.3} Satoh T, Sakurai E, Tada H & Masuda T. (2009). Ontogenesis of reticular framework of white pulp and marginal zone in homo spleen: immunohistochemical studies of fetal spleens from the 17th to 40th calendar week of gestation. Prison cell Tissue Res. , 336, 287-97. PMID: 19255788 DOI.
14. ↑ ^{14.0 14.ane 14.two fourteen.3} Afif A, Bouvier R, Buenerd A, Trouillas J & Mertens P. (2007). Development of the human fetal insular cortex: report of the gyration from thirteen to 28 gestational weeks. Brain Struct Funct , 212, 335-46. PMID: 17962979 DOI.
15. ↑ Kadhim HJ, Gadisseux JF & Evrard P. (1988). Topographical and cytological evolution of the glial phase during prenatal evolution of the human brain: histochemical and electron microscopic written report. J. Neuropathol. Exp. Neurol. , 47, 166-88. PMID: 3339373
16. ↑ ^{16.0 xvi.1} Hewer EE. The development of nerve endings in the human foetus. (1935) J Anat. 69(three):369-79. PMID 17104543
17. ↑ ^{17.0 17.one 17.ii} Garel C, Chantrel E, Brisse H, Elmaleh M, Luton D, Oury JF, Sebag Yard & Hassan Thousand. (2001). Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR Am J Neuroradiol , 22, 184-9. PMID: 11158907
18. ↑ Paquette LB, Jackson HA, Tavaré CJ, Miller DA & Panigrahy A. (2009). In utero eye development documented by fetal MR imaging. AJNR Am J Neuroradiol , 30, 1787-91. PMID: 19541779 DOI.
19. ↑ Kishimoto H, Yamada S, Kanahashi T, Yoneyama A, Imai H, Matsuda T, Takeda T, Kawai G & Suzuki S. (2016). Iii-dimensional imaging of palatal muscles in the human embryo and fetus: Development of levator veli palatini and clinical importance of the lesser palatine nervus. Dev. Dyn. , 245, 123-31. PMID: 26509917 DOI.
20. ↑ Maternal-Fetal Surgical Procedures. Walsh WF, Chescheir NC, Gillam-Krakauer Thousand, et al. Rockville (MD): Agency for Healthcare Research and Quality (The states); 2011 April. (Comparative Effectiveness Technical Briefs, No. v.) Study | Comparative Effectiveness Inquiry, Health Care
21. ↑ Braune W. An atlas of topographical beefcake later aeroplane sections of frozen bodies. (1877) Trans. by Edward Bellamy. Philadelphia: Lindsay and Blakiston.

Journals

• Seminars in Fetal & Neonatal Medicine

Reviews

Farley D & Dudley DJ. (2009). Fetal assessment during pregnancy. Pediatr. Clin. North Am. , 56, 489-504, Tabular array of Contents. PMID: 19501688 DOI.

Grivell RM, Wong L & Bhatia 5. (2009). Regimens of fetal surveillance for impaired fetal growth. Cochrane Database Syst Rev , , CD007113. PMID: 19160321 DOI.

Articles

Search PubMed

Search Pubmed: homo fetal evolution | fetal development | 2d Trimester | Third Trimester

Carnegie Fetal

Carnegie Collection - Fetal
Serial No.	Size CRL (mm)	Grade	Fixative	Embedding Medium	Plane	Thinness (µm)	Stain	Point Score	Sex	Year	Notes
95	forty										catalogued equally CRL 40 simply development suggests 50 phase. Spinal cord - Kunitomo (1920)[1] Colon - Lineback (1920)[2]
96	l										Encephalon venous sinuses - Streeter (1915)[3] Spinal cord - Kunitomo (1920)[1] Brain vascular - Streeter (1921)[4] Brain weight - Jenkins (1921)[5]
142	125										Spinal cord - Kunitomo (1920)[1]
145	33										Spinal cord - Kunitomo (1920)[1]
184	50										34 vertebrae, 31 spinal ganglia, Spinal cord - Kunitomo (1920)[i]
211	33										34 vertebra, 31 spinal ganglia, Spinal cord - Kunitomo (1920)[1]
217	45								Male		Genital - Spaulding (1921)[half dozen]
300	73										85 days, Bone ossification - Mall (1906)[vii]
362	thirty										Spinal cord - Kunitomo (1920)[1]
448	52										Colon - Lineback (1920)[2]
449	36										Spinal cord - Kunitomo (1920)[1]
538
590	21 to 23								Male person		Genital - Spaulding (1921)[half-dozen]
607	37								Male		Genital - Spaulding (1921)[6]
625	220										Temporomandibular articulation - Moffatt (1957)[viii]
662	80										Spinal cord - Kunitomo (1920)[1]
693	45								Male		Genital - Spaulding (1921)[6]
847	58.eight								Male		Genital - Spaulding (1921)[6]
858	57.25										Temporomandibular joint - Moffatt (1957)[8]
922	37
928	120										Spinal string - Kunitomo (1920)[one]
948	45								Male person		Genital - Spaulding (1921)[six]
972	37										34 vertebrae, xxx spinal ganglia, Spinal cord - Kunitomo (1920)[i]
1318	37										Temporomandibular joint - Moffatt (1957)[8]
1388	51								Female		Genital - Spaulding (1921)[6]
1455	78.5										Temporomandibular articulation - Moffatt (1957)[8]
1591	36										subcutaneous vascular plexus - Finley (1923)[9]
1656	67										34 vertebrae, Spinal cord - Kunitomo (1920)[1]
1686	xl								Male		Genital - Spaulding (1921)[6]
3990	49										Temporomandibular joint - Moffatt (1957)[8]
4473	43					twenty					Spinal string meninges - Sensenig (1951)[10]
4475	48					20					Spinal string meninges - Sensenig (1951)[10]
5652	49										Temporomandibular joint - Moffatt (1957)[8]
6581	75										Temporomandibular articulation - Moffatt (1957)[8]
7218	80					20 um					Spinal string meninges - Sensenig (1951)[10]
1597b	47								Female		Genital - Spaulding (1921)[six]
2250a	40								Female		Genital - Spaulding (1921)[6]
2250b	36								Female		Genital - Spaulding (1921)[6]
This table currently contains merely has embryo number information. Abbreviations Size - E. is the greatest length of the embryo and Ch. is the mean diameter of the chorion. Class - total class of the specimen and includes both its original quality and the status of the mounted sections. Embedding medium - alkane series (P) or a combination of celloidin and paraffin (C-P). Fixative - formalin (Formol), booze and formalin (Alc, formol), Bouin (Bouin solution) Stain - ? - unknown or not determined.
References ↑ 1.00 1.01 1.02 1.03 ane.04 1.05 1.06 1.07 1.08 1.09 ane.ten 1.eleven Kunitomo Yard. The development and reduction of the tail and of the caudal finish of the spinal cord (1920) Contrib. Embryol., Carnegie Inst. Launder. Publ. 272, 9: 163-198. ↑ 2.0 ii.1 Lineback PE. Studies on the longitudinal musculus of the human colon, with special reference to the development of the taeniae. (1920) Contrib. Embryol., Carnegie Inst. Wash. Publ. 50 ↑ Streeter GL. The evolution of the venous sinuses of the dura mater in the human embryo. (1915) Amer. J Anat.18: 145-178. ↑ Streeter GL. The developmental alterations in the vascular organisation of the brain of the human embryo. (1921) Contrib. Embryol., Carnegie Inst. Launder. eight:vii-38. ↑ Jenkins GB. Relative weight and volume of the component parts of the brain of the human embryo at different stages of development. (1921) Contrib. Embryol., Carnegie Inst. Wash., 59: 5-54. ↑ 6.00 6.01 6.02 half-dozen.03 six.04 half dozen.05 6.06 6.07 6.08 6.09 6.x Spaulding MH. The development of the external ballocks in the human being embryo. (1921) Contrib. Embryol., Carnegie Inst. Wash. Publ. 81, 13: 69 – 88. ↑ Mall FP. On ossification centers in man embryos less than 1 hundred days old. (1906) Amer. J Anat. v:433-458. ↑ 8.0 viii.1 8.2 8.iii eight.iv viii.5 8.vi Moffatt BC. The prenatal evolution of the human temporomandibular articulation. (1957) Carnegie Instn. Wash. Publ. 611, Contrib. Embryol., 36: . ↑ Finley EB. The development of the subcutaneous vascular plexus in the head of the human embryo. (1923) Contributions to Embryology Carnegie Institution No. 71: 155-161. ↑ 10.0 x.1 10.two Sensenig EC. The early development of the meninges of the spinal cord in human embryos. (1951) Contrib. Embryol., Carnegie Inst. Wash. Publ. 611.
Fertilization and Gestational Age - Crown-Rump Length (ultrasound) Fertilization Age (days) Gestational Historic period GA (calendar week.mean solar day) Crown-Rump Length (mm) 37 5.2 ane 38 5.iii two 39 5.four three 40 55 3 41 5.six four 42    Week 4 six 4 43 6.1 v 44 6.ii 6 45 6.3 7 46 6.4 8 47 6.v ix 48 6.half-dozen 10 49    Week 5 7 11 50 seven.ane 11 51 7.2 12 52 7.3 12 53 vii.four 13 54 7.five 14 55 7.6 fifteen 56    Week half dozen 8 17 57 8.1 18 58 viii.2 19 59 viii.iii 20 60 viii.4 21 61 eight.5 22 62 8.vi 22 63    Calendar week 7 9 23 64 nine.1 24 65 9.2 26 66 9.3 27 67 ix.4 28 68 9.5 29 69 9.6 31 lxx    Week 8 ten 34 71 10.ane 36 72 x.two 37 73 10.3 38 74 10.4 39 75 10.v 39 76 10.6 twoscore 77    Week ix xi 44 78 11.1 45 79 11.ii 47 80 11.3 48 81 eleven.4 52 82 11.5 55 83 11.6 56 84    Week x 12 57 85 12.1 58 86 12.two 60 87 12.3 61 88 12.4 63 89 12.5 64 90 12.6 65 91    Week eleven 13 68 92 13.1 70 93 xiii.2 72 94 13.3 74 95 113.four 76 96 135 77 97 13.6 80 98    Week 12 14 81 99 xiv.1 84 100 14.two 85 101 xiv.three 86 102 14.4 87 Reference: Table data measured by ultrasound, adapted from Westerway (2015) PDF and[1] Links: ultrasound | Fetal Development

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Cite this page: Hill, G.A. (2022, March fifteen) Embryology Fetal Evolution. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Fetal_Development

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1. ↑ Westerway SC, Davison A & Cowell S. (2000). Ultrasonic fetal measurements: new Australian standards for the new millennium. Aust North Z J Obstet Gynaecol , 40, 297-302. PMID: 11065037

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